Which wound healing phase involves the formation of granulation tissue?

The formation of granulation tissue occurs during the proliferative phase of wound healing. This phase is characterized by several key processes that work together to repair the site of injury. Granulation tissue is a new connective tissue that forms over the wound surface, consisting of a matrix of collagen, new blood vessels, and inflammatory cells, which all contribute to the healing process.

During this phase, fibroblasts play a critical role, as they proliferate and synthesize collagen and extracellular matrix, providing structural support for the new tissue. Additionally, angiogenesis, or the formation of new blood vessels, occurs to supply nutrients and oxygen to the healing tissue, which is vital for recovery. The formation of granulation tissue signifies that the wound is moving toward closure and that there is an active response to repair the damage.

In contrast, the inflammatory phase precedes the proliferative phase and focuses on the body's initial response to injury, which includes hemostasis and the clearance of debris. The maturation phase and remodeling phase occur later, where the initially formed tissue is strengthened and reorganized but does not primarily involve the formation of granulation tissue.